Synthesis, Biological Activities and Docking Studies of Novel 4-(Arylaminomethyl)benzamide Derivatives as Potential Tyrosine Kinase Inhibitors

Synthesis, Biological Activities and Docking Studies of Novel 4-(Arylaminomethyl)benzamide Derivatives as Potential Tyrosine Kinase Inhibitors

A number of new compounds containing the 4-(aminomethyl)benzamide fragment as a linker were designed and synthesized, and their biological activities were evaluated as potential anticancer agents. The cytotoxicity activity of the designed compounds was studied in two hematological and five solid cel...

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Bibliographic Details
Main Authors: Elena Kalinichenko, Aliaksandr Faryna, Viktoria Kondrateva, Alena Vlasova, Valentina Shevchenko, Alla Melnik, Olga Avdoshko, Alla Belko
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
4-(aminomethyl)benzamide
bcr-abl
protein kinase inhibitors
receptor tyrosine kinases
molecular docking
molecular dynamics
anticancer activity
Online Access:https://www.mdpi.com/1420-3049/24/19/3543

Internet

https://www.mdpi.com/1420-3049/24/19/3543

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