Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay

Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay

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Some N-substituted piperidine structures were synthesized and evaluated for cytotoxic activity against four different cell lines using the standard MTT assay method and Doxorubicin was used as the reference drug. The result of cytotoxic activity as a measurement of IC50 values revealed that three of...

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Main Authors: Farzaneh Fesahat, Mehdi Khoshneviszadeh, Alireza Foroumadi, Alireza Vahidi, Maryam Fereidounpour, Amirhossein Sakhteman
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2015-03-01
Series:Trends in Pharmaceutical Sciences
Online Access:http://tips.sums.ac.ir/article_42148_09f3ffba36db07b9ba239df029a3e2d6.pdf
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spelling doaj-14890ebae51b4877bc95e8d6fc0d18d32020-11-25T01:30:19ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522015-03-0111202442148Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assayFarzaneh FesahatMehdi KhoshneviszadehAlireza ForoumadiAlireza VahidiMaryam FereidounpourAmirhossein SakhtemanSome N-substituted piperidine structures were synthesized and evaluated for cytotoxic activity against four different cell lines using the standard MTT assay method and Doxorubicin was used as the reference drug. The result of cytotoxic activity as a measurement of IC50 values revealed that three of the synthesized compounds were active against breast cancer cell line. Compound 6a bearing hydroxyl at para position of piperidine ring was the most active compound within this series. The N-subtituted piperidine with propene substructure could be considered as a lead structure for further studies of structure activity relationship to develop more potent compounds in future.http://tips.sums.ac.ir/article_42148_09f3ffba36db07b9ba239df029a3e2d6.pdf
collection DOAJ
language English
format Article
sources DOAJ
author Farzaneh Fesahat
Mehdi Khoshneviszadeh
Alireza Foroumadi
Alireza Vahidi
Maryam Fereidounpour
Amirhossein Sakhteman
spellingShingle Farzaneh Fesahat
Mehdi Khoshneviszadeh
Alireza Foroumadi
Alireza Vahidi
Maryam Fereidounpour
Amirhossein Sakhteman
Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay
Trends in Pharmaceutical Sciences
author_facet Farzaneh Fesahat
Mehdi Khoshneviszadeh
Alireza Foroumadi
Alireza Vahidi
Maryam Fereidounpour
Amirhossein Sakhteman
author_sort Farzaneh Fesahat
title Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay
title_short Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay
title_full Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay
title_fullStr Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay
title_full_unstemmed Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay
title_sort cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using mtt assay
publisher Shiraz University of Medical Sciences
series Trends in Pharmaceutical Sciences
issn 2423-5652
publishDate 2015-03-01
description Some N-substituted piperidine structures were synthesized and evaluated for cytotoxic activity against four different cell lines using the standard MTT assay method and Doxorubicin was used as the reference drug. The result of cytotoxic activity as a measurement of IC50 values revealed that three of the synthesized compounds were active against breast cancer cell line. Compound 6a bearing hydroxyl at para position of piperidine ring was the most active compound within this series. The N-subtituted piperidine with propene substructure could be considered as a lead structure for further studies of structure activity relationship to develop more potent compounds in future.
url http://tips.sums.ac.ir/article_42148_09f3ffba36db07b9ba239df029a3e2d6.pdf
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