Considering the APOE locus in Alzheimer’s disease polygenic scores in the Health and Retirement Study: a longitudinal panel study

Considering the APOE locus in Alzheimer’s disease polygenic scores in the Health and Retirement Study: a longitudinal panel study

Abstract Background Polygenic scores are a strategy to aggregate the small, additive effects of single nucleotide polymorphisms across the genome. With phenotypes like Alzheimer’s disease, which have a strong and well-established genomic locus (APOE), the cumulative effect of genetic variants outsid...

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Bibliographic Details
Main Authors: Erin B. Ware, Jessica D. Faul, Colter M. Mitchell, Kelly M. Bakulski
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Medical Genomics
Subjects:
Polygenic score
Alzheimer’s disease
Dementia
Apolipoprotein E
P-value
Thresholding
Online Access:http://link.springer.com/article/10.1186/s12920-020-00815-9

Internet

http://link.springer.com/article/10.1186/s12920-020-00815-9

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