DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development.

DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development.

During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic instability spontaneously generates during the process of tumorigenesis. Here, we show that precancerous DNA lesions induced by oncogene acceleration,...

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Bibliographic Details
Main Authors: Yosuke Ichijima, Ken-ichi Yoshioka, Yoshiko Yoshioka, Keitaro Shinohe, Hiroaki Fujimori, Junya Unno, Masatoshi Takagi, Hidemasa Goto, Masaki Inagaki, Shuki Mizutani, Hirobumi Teraoka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2809090?pdf=render

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http://europepmc.org/articles/PMC2809090?pdf=render

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