Artificially decreasing cortical tension generates aneuploidy in mouse oocytes

Artificially decreasing cortical tension generates aneuploidy in mouse oocytes

The developmental potential of human and murine oocytes is predicted by their mechanical properties. Here the authors show that artificial reduction of cortex tension produces aneuploid mouse oocytes and speculate that this may contribute to the high aneuploidy rate typical of female meiosis.

Bibliographic Details
Main Authors: Isma Bennabi, Flora Crozet, Elvira Nikalayevich, Agathe Chaigne, Gaëlle Letort, Marion Manil-Ségalen, Clément Campillo, Clotilde Cadart, Alice Othmani, Rafaele Attia, Auguste Genovesio, Marie-Hélène Verlhac, Marie-Emilie Terret
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15470-y

Internet

https://doi.org/10.1038/s41467-020-15470-y

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