Direct and Auger Electron-Induced, Single- and Double-Strand Breaks on Plasmid DNA Caused by 99mTc-Labeled Pyrene Derivatives and the Effect of Bonding Distance.

Direct and Auger Electron-Induced, Single- and Double-Strand Breaks on Plasmid DNA Caused by 99mTc-Labeled Pyrene Derivatives and the Effect of Bonding Distance.

It is evident that 99mTc causes radical-mediated DNA damage due to Auger electrons, which were emitted simultaneously with the known γ-emission of 99mTc. We have synthesized a series of new 99mTc-labeled pyrene derivatives with varied distances between the pyrene moiety and the radionuclide. The pyr...

Full description

Bibliographic Details
Main Authors: Falco Reissig, Constantin Mamat, Joerg Steinbach, Hans-Juergen Pietzsch, Robert Freudenberg, Carlos Navarro-Retamal, Julio Caballero, Joerg Kotzerke, Gerd Wunderlich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5008623?pdf=render

Internet

http://europepmc.org/articles/PMC5008623?pdf=render

Similar Items