The Relative Role of Toxins A and B in the Virulence of <i>Clotridioides difficile</i>

The Relative Role of Toxins A and B in the Virulence of <i>Clotridioides difficile</i>

Most pathogenic strains of <i>C. difficile</i> possess two large molecular weight single unit toxins with four similar functional domains. The toxins disrupt the actin cytoskeleton of intestinal epithelial cells leading to loss of tight junctions, which ultimately manifests as diarrhea i...

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Bibliographic Details
Main Authors: Andrew M. Skinner, S. Tyler Phillips, Michelle M. Merrigan, Kevin J. O’Leary, Susan P. Sambol, Farida Siddiqui, Lance R. Peterson, Dale N. Gerding, Stuart Johnson
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Journal of Clinical Medicine
Subjects:
<i>Clostridioides difficile</i>
molecular epidemiology
toxinotyping
restriction endonuclease analysis
toxin A
toxin B
Online Access:https://www.mdpi.com/2077-0383/10/1/96

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https://www.mdpi.com/2077-0383/10/1/96

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