Inferring short-range linkage information from sequencing chromatograms.

Direct Sanger sequencing of viral genome populations yields multiple ambiguous sequence positions. It is not straightforward to derive linkage information from sequencing chromatograms, which in turn hampers the correct interpretation of the sequence data. We present a method for determining the var...

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Bibliographic Details
Main Authors: Bastian Beggel, Maria Neumann-Fraune, Rolf Kaiser, Jens Verheyen, Thomas Lengauer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3869653?pdf=render