A dynamic model of interactions of Ca2+, calmodulin, and catalytic subunits of Ca2+/calmodulin-dependent protein kinase II.

During the acquisition of memories, influx of Ca2+ into the postsynaptic spine through the pores of activated N-methyl-D-aspartate-type glutamate receptors triggers processes that change the strength of excitatory synapses. The pattern of Ca2+influx during the first few seconds of activity is interp...

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Bibliographic Details
Main Authors: Shirley Pepke, Tamara Kinzer-Ursem, Stefan Mihalas, Mary B Kennedy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2820514?pdf=render