A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells.

A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells.

The JAK2/STAT3 signaling pathway plays a critical role in tumorigenesis, and has been suggested as a potential molecular target for anti-melanoma therapeutics. However, few JAK2 inhibitors were being tested for melanoma therapy. In this study, eight amentoflavone analogues were evaluated for their a...

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Bibliographic Details
Main Authors: Ke-Jia Wu, Jie-Min Huang, Hai-Jing Zhong, Zhen-Zhen Dong, Kasipandi Vellaisamy, Jin-Jian Lu, Xiu-Ping Chen, Pauline Chiu, Daniel W J Kwong, Quan-Bin Han, Dik-Lung Ma, Chung-Hang Leung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5453690?pdf=render

Internet

http://europepmc.org/articles/PMC5453690?pdf=render

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