Dopamine Receptor D3 Expression Is Altered in CD4+ T-Cells From Parkinson's Disease Patients and Its Pharmacologic Inhibition Attenuates the Motor Impairment in a Mouse Model

Dopamine Receptor D3 Expression Is Altered in CD4+ T-Cells From Parkinson's Disease Patients and Its Pharmacologic Inhibition Attenuates the Motor Impairment in a Mouse Model

Neuroinflammation constitutes a fundamental process involved in Parkinson's disease (PD). Microglial cells play a central role in the outcome of neuroinflammation and consequent neurodegeneration of dopaminergic neurons in the substantia nigra. Current evidence indicates that CD4+ T-cells infil...

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Bibliographic Details
Main Authors: Daniela Elgueta, Francisco Contreras, Carolina Prado, Andro Montoya, Valentina Ugalde, Ornella Chovar, Roque Villagra, Claudio Henríquez, Miguel A. Abellanas, María S. Aymerich, Rarael Franco, Rodrigo Pacheco
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
neuroinflammation
neurodegeneration
Parkinson's disease patients
MPTP mouse model
dopamine receptors
CD4+ T-cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00981/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00981/full

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