Genetic and environmental determinants of human TCR repertoire diversity

Genetic and environmental determinants of human TCR repertoire diversity

Abstract T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules. However, the impact of host immunogenetic var...

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Bibliographic Details
Main Authors: Chirag Krishna, Diego Chowell, Mithat Gönen, Yuval Elhanati, Timothy A. Chan
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Immunity & Ageing
Subjects:
Major histocompatibility complex
Heterozygote advantage
T cell receptor repertoire
Infection
Aging
Immunogenetics
Online Access:http://link.springer.com/article/10.1186/s12979-020-00195-9

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http://link.springer.com/article/10.1186/s12979-020-00195-9

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