Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

Multidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer.

Bibliographic Details
Main Authors:	Hai Wang, Zan Gao, Xuanyou Liu, Pranay Agarwal, Shuting Zhao, Daniel W. Conroy, Guang Ji, Jianhua Yu, Christopher P. Jaroniec, Zhenguo Liu, Xiongbin Lu, Xiaodong Li, Xiaoming He
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-02915-8

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spelling	doaj-1411ae0882f24d7aa8a64b2cb0d42b7e2021-05-11T09:59:53ZengNature Publishing GroupNature Communications2041-17232018-02-019111610.1038/s41467-018-02915-8Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistanceHai Wang0Zan Gao1Xuanyou Liu2Pranay Agarwal3Shuting Zhao4Daniel W. Conroy5Guang Ji6Jianhua Yu7Christopher P. Jaroniec8Zhenguo Liu9Xiongbin Lu10Xiaodong Li11Xiaoming He12Department of Biomedical Engineering, The Ohio State UniversityDepartment of Mechanical and Aerospace Engineering, University of VirginiaDivision of Cardiovascular Medicine, Center for Precision Medicine, University of Missouri School of MedicineDepartment of Biomedical Engineering, The Ohio State UniversityDepartment of Biomedical Engineering, The Ohio State UniversityDepartment of Chemistry and Biochemistry, The Ohio State UniversityInstitute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese MedicineComprehensive Cancer Center, The Ohio State UniversityDepartment of Chemistry and Biochemistry, The Ohio State UniversityDavis Heart and Lung Research Institute, The Ohio State UniversityDepartment of Medical and Molecular Genetics and Melvin and Bren Simon Cancer Center, Indiana University School of MedicineDepartment of Mechanical and Aerospace Engineering, University of VirginiaDepartment of Biomedical Engineering, The Ohio State UniversityMultidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer.https://doi.org/10.1038/s41467-018-02915-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hai Wang Zan Gao Xuanyou Liu Pranay Agarwal Shuting Zhao Daniel W. Conroy Guang Ji Jianhua Yu Christopher P. Jaroniec Zhenguo Liu Xiongbin Lu Xiaodong Li Xiaoming He
spellingShingle	Hai Wang Zan Gao Xuanyou Liu Pranay Agarwal Shuting Zhao Daniel W. Conroy Guang Ji Jianhua Yu Christopher P. Jaroniec Zhenguo Liu Xiongbin Lu Xiaodong Li Xiaoming He Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance Nature Communications
author_facet	Hai Wang Zan Gao Xuanyou Liu Pranay Agarwal Shuting Zhao Daniel W. Conroy Guang Ji Jianhua Yu Christopher P. Jaroniec Zhenguo Liu Xiongbin Lu Xiaodong Li Xiaoming He
author_sort	Hai Wang
title	Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_short	Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_full	Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_fullStr	Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_full_unstemmed	Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_sort	targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-02-01
description	Multidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer.
url	https://doi.org/10.1038/s41467-018-02915-8
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Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

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