Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

Multidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer.

Bibliographic Details
Main Authors: Hai Wang, Zan Gao, Xuanyou Liu, Pranay Agarwal, Shuting Zhao, Daniel W. Conroy, Guang Ji, Jianhua Yu, Christopher P. Jaroniec, Zhenguo Liu, Xiongbin Lu, Xiaodong Li, Xiaoming He
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-02915-8

Internet

https://doi.org/10.1038/s41467-018-02915-8

Similar Items