Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
Multidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer.
Bibliographic Details
| Main Authors: |
Hai Wang,
Zan Gao,
Xuanyou Liu,
Pranay Agarwal,
Shuting Zhao,
Daniel W. Conroy,
Guang Ji,
Jianhua Yu,
Christopher P. Jaroniec,
Zhenguo Liu,
Xiongbin Lu,
Xiaodong Li,
Xiaoming He |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-02915-8
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