Anticancer Alkaloid Lamellarins Inhibit Protein Kinases

Anticancer Alkaloid Lamellarins Inhibit Protein Kinases

Lamellarins, a family of hexacyclic pyrrole alkaloids originally isolated from marine invertebrates, display promising anti-tumor activity. They induce apoptotic cell death through multi-target mechanisms, including inhibition of topoisomerase I, interaction with DNA and direct effects on mitochondr...

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Bibliographic Details
Main Authors: Laurent Meijer, Masatomo Iwao, Fumito Ishibashi, Somsak Rucirawat, Poonsakdi Ploypradith, Olivier Lozach, Yoan Ferandin, Nolwenn Trinkler, Dianne Baunbæk
Format: Article
Language:English
Published: MDPI AG 2008-10-01
Series:Marine Drugs
Subjects:
lamellarin
kinase inhibitor
cyclin-dependent kinases
CK1
DYRK-1A
GSK-3
Online Access:http://www.mdpi.com/1660-3397/6/4/514/

Internet

http://www.mdpi.com/1660-3397/6/4/514/

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