Pharmacokinetics of Human Red Blood Cell Microparticles Prepared Using High-Pressure Extrusion Method

Pharmacokinetics of Human Red Blood Cell Microparticles Prepared Using High-Pressure Extrusion Method

Red blood cell microparticles (RMPs) is a high potency hemostatic agent, which may serve as a viable therapeutic approach. They generate thrombin in vitro and effective in arresting bleeding in animal bleeding models. However, prior to ascertaining the clinical efficacy of RMPs, detailed preclinical...

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Bibliographic Details
Main Authors: Wenche Jy, Ashish K. Rehni, Carlos Bidot, Hever Navarro-Quero, Conner R. Haase, Sebastian Koch, Yeon S. Ahn, Kunjan R. Dave
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
hemostasis
dose response
particle size
shelf-life
half-life
volume of distribution
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00599/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00599/full

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