Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis

2-Piperidineethanol (1) and its corresponding N-protected aldehyde (2) were used for the synthesis of several natural and synthetic compounds. The existence of a stereocenter at position 2 of the piperidine skeleton and the presence of an easily-functionalized group, such as the alcohol, set 1 as a...

Full description

Bibliographic Details
Main Authors:	Dario Perdicchia, Michael S. Christodoulou, Gaia Fumagalli, Francesco Calogero, Cristina Marucci, Daniele Passarella
Format:	Article
Language:	English
Published:	MDPI AG 2015-12-01
Series:	International Journal of Molecular Sciences
Subjects:	2-piperidineethanol piperidine alkaloids enzymatic resolution alkaloid synthesis
Online Access:	http://www.mdpi.com/1422-0067/17/1/17

id	doaj-13f3e8811c0148e4aded313aea946783
record_format	Article
spelling	doaj-13f3e8811c0148e4aded313aea9467832020-11-24T23:26:37ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-12-011711710.3390/ijms17010017ijms17010017Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented SynthesisDario Perdicchia0Michael S. Christodoulou1Gaia Fumagalli2Francesco Calogero3Cristina Marucci4Daniele Passarella5Dipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, ItalyDipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, ItalyDipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, ItalyDipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, ItalyDipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, ItalyDipartimento di Chimica, Universita degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy2-Piperidineethanol (1) and its corresponding N-protected aldehyde (2) were used for the synthesis of several natural and synthetic compounds. The existence of a stereocenter at position 2 of the piperidine skeleton and the presence of an easily-functionalized group, such as the alcohol, set 1 as a valuable starting material for enantioselective synthesis. Herein, are presented both synthetic and enzymatic methods for the resolution of the racemic 1, as well as an overview of synthesized natural products starting from the enantiopure 1.http://www.mdpi.com/1422-0067/17/1/172-piperidineethanolpiperidine alkaloidsenzymatic resolutionalkaloid synthesis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dario Perdicchia Michael S. Christodoulou Gaia Fumagalli Francesco Calogero Cristina Marucci Daniele Passarella
spellingShingle	Dario Perdicchia Michael S. Christodoulou Gaia Fumagalli Francesco Calogero Cristina Marucci Daniele Passarella Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis International Journal of Molecular Sciences 2-piperidineethanol piperidine alkaloids enzymatic resolution alkaloid synthesis
author_facet	Dario Perdicchia Michael S. Christodoulou Gaia Fumagalli Francesco Calogero Cristina Marucci Daniele Passarella
author_sort	Dario Perdicchia
title	Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis
title_short	Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis
title_full	Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis
title_fullStr	Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis
title_full_unstemmed	Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis
title_sort	enzymatic kinetic resolution of 2-piperidineethanol for the enantioselective targeted and diversity oriented synthesis
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2015-12-01
description	2-Piperidineethanol (1) and its corresponding N-protected aldehyde (2) were used for the synthesis of several natural and synthetic compounds. The existence of a stereocenter at position 2 of the piperidine skeleton and the presence of an easily-functionalized group, such as the alcohol, set 1 as a valuable starting material for enantioselective synthesis. Herein, are presented both synthetic and enzymatic methods for the resolution of the racemic 1, as well as an overview of synthesized natural products starting from the enantiopure 1.
topic	2-piperidineethanol piperidine alkaloids enzymatic resolution alkaloid synthesis
url	http://www.mdpi.com/1422-0067/17/1/17
work_keys_str_mv	AT darioperdicchia enzymatickineticresolutionof2piperidineethanolfortheenantioselectivetargetedanddiversityorientedsynthesis AT michaelschristodoulou enzymatickineticresolutionof2piperidineethanolfortheenantioselectivetargetedanddiversityorientedsynthesis AT gaiafumagalli enzymatickineticresolutionof2piperidineethanolfortheenantioselectivetargetedanddiversityorientedsynthesis AT francescocalogero enzymatickineticresolutionof2piperidineethanolfortheenantioselectivetargetedanddiversityorientedsynthesis AT cristinamarucci enzymatickineticresolutionof2piperidineethanolfortheenantioselectivetargetedanddiversityorientedsynthesis AT danielepassarella enzymatickineticresolutionof2piperidineethanolfortheenantioselectivetargetedanddiversityorientedsynthesis
_version_	1725554205780869120

Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis

Similar Items