Transcriptional Programs Driving Shear Stress-Induced Differentiation of Kidney Proximal Tubule Cells in Culture

Transcriptional Programs Driving Shear Stress-Induced Differentiation of Kidney Proximal Tubule Cells in Culture

Cultured cell models are an essential complement to dissecting kidney proximal tubule (PT) function in health and disease but do not fully recapitulate key features of this nephron segment. We recently determined that culture of opossum kidney (OK) cells under continuous orbital shear stress (OSS) s...

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Bibliographic Details
Main Authors: Hyun Jung Park, Zhenjiang Fan, Yulong Bai, Qidong Ren, Youssef Rbaibi, Kimberly R. Long, Megan L. Gliozzi, Natalie Rittenhouse, Joseph D. Locker, Amanda C. Poholek, Ora A. Weisz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
kidney
proximal tubule
endocytosis
cell culture
shear stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.587358/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.587358/full

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