Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats

Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats

Abstract Background Laminectomy is usually classed as a common orthopedic surgery, but postoperative epidural fibrosis often leads to less-than-desirable clinical outcomes. As demonstrated by prior studies, emodin (EMO) exerts an anti-fibrotic effect. Here, we carried out investigation into the inhi...

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Bibliographic Details
Main Authors: Guirun Xiong, Hui Chen, Qi Wan, Jihang Dai, Yu Sun, Jingcheng Wang, Xiaolei Li
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Emodin
Fibroblast apoptosis
PERK
Epidural fibrosis
Online Access:http://link.springer.com/article/10.1186/s13018-019-1357-9

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http://link.springer.com/article/10.1186/s13018-019-1357-9

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