Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth.

Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth.

BACKGROUND:Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. Pre-clinical models clearly demonstrate that chemotherapy can synergize with immunotherapy, raising the question how the immune system can be mobilized to generate anti-tumor immune responses in the cont...

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Bibliographic Details
Main Authors: Robbert G van der Most, Andrew J Currie, Amanda L Cleaver, Joanne Salmons, Anna K Nowak, Sathish Mahendran, Irma Larma, Amy Prosser, Bruce W S Robinson, Mark J Smyth, Anthony A Scalzo, Mariapia A Degli-Esposti, Richard A Lake
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2734989?pdf=render

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http://europepmc.org/articles/PMC2734989?pdf=render

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