Serum extracellular vesicles containing MIAT induces atrial fibrosis, inflammation and oxidative stress to promote atrial remodeling and atrial fibrillation via blockade of miR‐485‐5p‐mediated CXCL10 inhibition

Serum extracellular vesicles containing MIAT induces atrial fibrosis, inflammation and oxidative stress to promote atrial remodeling and atrial fibrillation via blockade of miR‐485‐5p‐mediated CXCL10 inhibition

Abstract Background Atrial fibrillation (AF), a supraventricular arrhythmia that impairs cardiac function, is a main source of morbidity and mortality. Serum‐derived extracellular vesicles (EVs) have been identified to carry potential biomarker or target for the diagnosis and treatment of AF. We int...

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Bibliographic Details
Main Authors: Yingwei Chen, Xiaojie Chen, Haiyu Li, Yunpeng Li, Dong Cheng, Yi Tang, Haiqiang Sang
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Clinical and Translational Medicine
Subjects:
atrial fibrillation
CXCL10
extracellular vesicles
fibrosis
inflammation
MIAT
Online Access:https://doi.org/10.1002/ctm2.482

Internet

https://doi.org/10.1002/ctm2.482

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