The Blockade of TACE-Dependent EGF Receptor Activation by Losartan-Erlotinib Combination Attenuates Renal Fibrosis Formation in 5/6-Nephrectomized Rats Under Vitamin D Deficiency

The Blockade of TACE-Dependent EGF Receptor Activation by Losartan-Erlotinib Combination Attenuates Renal Fibrosis Formation in 5/6-Nephrectomized Rats Under Vitamin D Deficiency

Chronic kidney disease (CKD) has been considered a major public health issue. In addition to cardiovascular diseases and infections, hypovitaminosis D has been considered a non-traditional aggravating factor for CKD progression. Interstitial fibrosis is a hallmark of CKD strongly correlated with det...

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Bibliographic Details
Main Authors: Janaína Garcia Gonçalves, Daniele Canale, Ana Carolina de Bragança, Antonio Carlos Seguro, Maria Heloisa Massola Shimizu, Rildo Aparecido Volpini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Medicine
Subjects:
chronic kidney disease
TACE
renal fibrosis
vitamin D deficiency
erlotinib
experimental model
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.609158/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2020.609158/full

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