The presence of cortical neurons in striatal-cortical co-cultures alters the effects of dopamine and BDNF on Medium Spiny Neuron dendritic development

The presence of cortical neurons in striatal-cortical co-cultures alters the effects of dopamine and BDNF on Medium Spiny Neuron dendritic development

Medium spiny neurons (MSNs) are the major striatal neuron and receive synaptic input from both glutamatergic and dopaminergic afferents. These synapses are made on MSN dendritic spines, which undergo density and morphology changes in association with numerous disease and experience-dependent states...

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Bibliographic Details
Main Authors: Rachel D Penrod, Justin eCampagna, Travis ePanneck, Laura ePreese, Lorene M Lanier
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Dendritic Spines
Dopamine
BDNF
development
Striatum
in vitro
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00269/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00269/full

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