InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity

InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity

Abstract Background Candida albicans (C. albicans) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca2+ levels via the inositol 1,4,5-trisphosphate receptor (InsP3R) plays a critical role in this process. However, the molecular pathways linking the InsP3R-mediated incr...

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Bibliographic Details
Main Authors: Long Yang, Wenwen Gu, King-Ho Cheung, Lan Yan, Benjamin Chun-Kit Tong, Yuanying Jiang, Jun Yang
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Biology
Subjects:
Inositol 1,4,5-trisphosphate receptors (InsP3R)
Exocyst complex component 2 (SEC5)
Tank-binding kinase 1 (TBK1)
Antifungal innate immune response
Online Access:http://link.springer.com/article/10.1186/s12915-018-0507-6

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http://link.springer.com/article/10.1186/s12915-018-0507-6

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