miR-205 Expression Elevated With EDS Treatment and Induced Leydig Cell Apoptosis by Targeting RAP2B via the PI3K/AKT Signaling Pathway

miR-205 Expression Elevated With EDS Treatment and Induced Leydig Cell Apoptosis by Targeting RAP2B via the PI3K/AKT Signaling Pathway

The adult Leydig cells (ALCs), originated from stem Leydig cells (SLCs), can secrete testosterone which is essential for germ cell development and sexual behavior maintenance. As a synthetic compound, ethane dimethane sulfonate (EDS), a well-known alkylating agent, has been reported to specifically...

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Bibliographic Details
Main Authors: Yang Cui, Rui Chen, Lin Ma, Wenjing Yang, Mingyue Chen, Yanghai Zhang, Shuai Yu, Wuzi Dong, Wenxian Zeng, Xianyong Lan, Chuanying Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pig
Leydig cell
mRNA transcripts
miR-205
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00448/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00448/full

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