ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

Abstract Cancer cells are frequently confronted with metabolic stress in tumor microenvironments due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death through ROS-induced apoptosis. However, cancer cells can adapt to it by altering the metabolic pathways. AMPK an...

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Bibliographic Details
Main Authors: Yang Zhao, Xingbin Hu, Yajing Liu, Shumin Dong, Zhaowei Wen, Wanming He, Shuyi Zhang, Qiong Huang, Min Shi
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Molecular Cancer
Subjects:
Reactive oxygen species
Metabolic stress
AMPK
AKT
mTOR
FOXO
Online Access:http://link.springer.com/article/10.1186/s12943-017-0648-1

Internet

http://link.springer.com/article/10.1186/s12943-017-0648-1

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