Response of Renal Podocytes to Excessive Hydrostatic Pressure: a Pathophysiologic Cascade in a Malignant Hypertension Model

Response of Renal Podocytes to Excessive Hydrostatic Pressure: a Pathophysiologic Cascade in a Malignant Hypertension Model

Background/Aims: Renal injuries induced by increased intra-glomerular pressure coincide with podocyte detachment from the glomerular basement membrane (GBM). In previous studies, it was demonstrated that mesangial cells have a crucial role in the pathogenesis of malignant hypertension. However, the...

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Bibliographic Details
Main Authors: Ramzia Abu Hamad, Sylvia Berman, Yafit Hachmo, Moshe Stark, Fadia Hasan, Keren Doenyas-Barak, Shai Efrati
Format: Article
Language:English
Published: Karger Publishers 2017-12-01
Series:Kidney & Blood Pressure Research
Subjects:
Angiotensin-II
Apoptosis
TGFβ1
Detachment/loss of viable podocytes
Podocin
Integrinβ1
Online Access:https://www.karger.com/Article/FullText/485774

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https://www.karger.com/Article/FullText/485774

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