Hierarchical clustering of breast cancer methylomes revealed differentially methylated and expressed breast cancer genes.

Oncogenic transformation of normal cells often involves epigenetic alterations, including histone modification and DNA methylation. We conducted whole-genome bisulfite sequencing to determine the DNA methylomes of normal breast, fibroadenoma, invasive ductal carcinomas and MCF7. The emergence, disap...

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Bibliographic Details
Main Authors: I-Hsuan Lin, Dow-Tien Chen, Yi-Feng Chang, Yu-Ling Lee, Chia-Hsin Su, Ching Cheng, Yi-Chien Tsai, Swee-Chuan Ng, Hsiao-Tan Chen, Mei-Chen Lee, Hong-Wei Chen, Shih-Hui Suen, Yu-Cheng Chen, Tze-Tze Liu, Chuan-Hsiung Chang, Ming-Ta Hsu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0118453