Hf(OTf)<sub>4</sub> as a Highly Potent Catalyst for the Synthesis of Mannich Bases under Solvent-Free Conditions

Hf(OTf)<sub>4</sub> as a Highly Potent Catalyst for the Synthesis of Mannich Bases under Solvent-Free Conditions

Hf(OTf)<sub>4</sub> was identified as a highly potent catalyst (0.1&#8722;0.5 mol%) for three-component Mannich reaction under solvent-free conditions. Hf(OTf)<sub>4</sub>-catalyzed Mannich reaction exhibited excellent regioselectivity and diastereoselectivity when alkyl...

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Bibliographic Details
Main Authors: Shuai-Bo Han, Jing-Ying Wei, Xiao-Chong Peng, Rong Liu, Shan-Shan Gong, Qi Sun
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
hafnium triflate
mannich reaction
solvent-free
β-amino carbonyl compound
mechanism
Online Access:https://www.mdpi.com/1420-3049/25/2/388

Internet

https://www.mdpi.com/1420-3049/25/2/388

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