The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1α (HIF-1α) protein levels in endothelial cells under hypoxia.

The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1α (HIF-1α) protein levels in endothelial cells under hypoxia.

The tyrosine phosphatase SHP-1 negatively influences endothelial function, such as VEGF signaling and reactive oxygen species (ROS) formation, and has been shown to influence angiogenesis during tissue ischemia. In ischemic tissues, hypoxia induced angiogenesis is crucial for restoring oxygen supply...

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Bibliographic Details
Main Authors: Stefan K Alig, Yvonn Stampnik, Joachim Pircher, Raffaela Rotter, Erik Gaitzsch, Andrea Ribeiro, Markus Wörnle, Florian Krötz, Hanna Mannell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370726?pdf=render

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http://europepmc.org/articles/PMC4370726?pdf=render

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