Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products

Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products

Natural products originating from marine and plant materials are a rich source of chemical diversity and unique antimicrobials. Using an established in vitro model of HIV-1 latency, we screened 257 pure compounds from a marine natural product library and identified 4 (psammaplin A, aplysiatoxin, deb...

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Bibliographic Details
Main Authors: Khumoekae Richard, David E. Williams, E. Dilip de Silva, Mark A. Brockman, Zabrina L. Brumme, Raymond J. Andersen, Ian Tietjen
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Viruses
Subjects:
HIV-1
latency reversal
HIV reservoir
natural products
antivirals
shock-and-kill
psammaplin A
aplysiatoxin
debromoaplysiatoxin
alotaketal C
Online Access:http://www.mdpi.com/1999-4915/10/7/348

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http://www.mdpi.com/1999-4915/10/7/348

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