Phosphinotripeptidic Inhibitors of Leucylaminopeptidases

Phosphinotripeptidic Inhibitors of Leucylaminopeptidases

Phosphinate pseudopeptide are analogs of peptides containing phosphinate moiety in a place of the amide bond. Due to this, the organophosphorus fragment resembles the tetrahedral transition state of the amide bond hydrolysis. Additionally, it is also capable of coordinating metal ions, for example,...

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Bibliographic Details
Main Authors: Michał Jewgiński, Kinga Haremza, Jesús M. de los Santos, Zouhair Es Sbai, Bartosz Oszywa, Małgorzata Pawełczak, Francisco Palacios, Rafał Latajka
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
molecular modeling
LAP inhibitors
barley aminopeptidase inhibitor
phosphinate pseudopeptide
ligand-enzyme interaction
organophosphorus compound
Online Access:https://www.mdpi.com/1422-0067/22/10/5090

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https://www.mdpi.com/1422-0067/22/10/5090

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