Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway

Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway

Mounting evidence has demonstrated that microRNA-1224 (miR-1224) is commonly downregulated and serves as a tumor suppressor in multiple malignancies. However, the role and mechanisms responsible for miR-1224 in hepatocellular carcinoma (HCC) remain unclear. In this study, we found that the expressio...

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Bibliographic Details
Main Authors: Shikun Yang, Wei Jiang, Wenjie Yang, Chao Yang, Xinchen Yang, Keyan Chen, Yuanchang Hu, Gefenqiang Shen, Ling Lu, Feng Cheng, Feng Zhang, Jianhua Rao, Xuehao Wang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
miR-1224
hepatocellular carcinoma
proliferation
YAP
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000081

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http://www.sciencedirect.com/science/article/pii/S2162253121000081

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