The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC

The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC

Previous studies have shown that oral administration of the NMDAR modulator NYX-2925 alleviates pain in several animal models of neuropathic pain and this appears to be through mPFC, but not spinal, mediated mechanisms. While much is known about the impact of neuropathic pain on NMDAR-mediated signa...

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Bibliographic Details
Main Authors: Gladys Morrison, Marina N. Asiedu, Jessica M. Priebe, Jacqueline Dunning, Nayereh Ghoreishi-Haack, Roger A. Kroes, M. Scott Bowers, Amanda L. Barth, Cassia N. Cearley, Joseph R. Moskal
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Neurobiology of Pain
Subjects:
Neuropathic pain
Medial prefrontal cortex
NMDAR's
Src kinase
Chronic Constriction injury (CCI)
Online Access:http://www.sciencedirect.com/science/article/pii/S2452073X19300145

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http://www.sciencedirect.com/science/article/pii/S2452073X19300145

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