Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

Abstract Background Mutations in isocitrate dehydrogenase 1 (IDH1) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D-2-hydroxyglutarate (D-2-HG) at the expense of α-ketoglutarate (α-KG) and NADPH. To overcome metaboli...

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Bibliographic Details
Main Authors: Tom H. Peeters, Krissie Lenting, Vincent Breukels, Sanne A. M. van Lith, Corina N. A. M. van den Heuvel, Remco Molenaar, Arno van Rooij, Ron Wevers, Paul N. Span, Arend Heerschap, William P. J. Leenders
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cancer & Metabolism
Subjects:
IDH mutations
Metabolism
EGCG
Radiotherapy
Glutamate
Online Access:http://link.springer.com/article/10.1186/s40170-019-0198-7

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http://link.springer.com/article/10.1186/s40170-019-0198-7

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