Structure-to-Efficacy Relationship of HPMA-Based Nanomedicines: The Tumor Spheroid Penetration Study

Structure-to-Efficacy Relationship of HPMA-Based Nanomedicines: The Tumor Spheroid Penetration Study

Nanomedicines are a novel class of therapeutics that benefit from the nano dimensions of the drug carrier. These nanosystems are highly advantageous mainly within cancer treatment due to their enhanced tumor accumulation. Monolayer tumor cells frequently used in routine preclinical assessment of nan...

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Bibliographic Details
Main Authors: Júlia Kudláčová, Lenka Kotrchová, Libor Kostka, Eva Randárová, Marcela Filipová, Olga Janoušková, Jun Fang, Tomáš Etrych
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceutics
Subjects:
HPMA polymers
pirarubicin
tumor spheroids
penetration
cytotoxicity
Online Access:https://www.mdpi.com/1999-4923/12/12/1242

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https://www.mdpi.com/1999-4923/12/12/1242

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