RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia

RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia

Abstract Background Additional sex combs-like 1 (ASXL1) mutations have been described in all forms of myeloid neoplasms including chronic myelomonocytic leukemia (CMML) and associated with inferior outcomes, yet the molecular pathogenesis of ASXL1 mutations (ASXL1-MT) remains poorly understood. Tran...

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Bibliographic Details
Main Authors: Rabindranath Bera, Ming-Chun Chiu, Ying-Jung Huang, Tung-Huei Lin, Ming-Chung Kuo, Lee-Yung Shih
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Hematology & Oncology
Subjects:
ASXL1
RUNX1
Myeloid transformation
HIF-1α
ID1
Online Access:http://link.springer.com/article/10.1186/s13045-019-0789-3

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http://link.springer.com/article/10.1186/s13045-019-0789-3

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