Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction.

Dopamine D1 receptor (DRD1) modulates opioid reinforcement, reward, and opioid-induced neuroadaptation. We propose that DRD1 polymorphism affects susceptibility to opioid dependence (OD), the efficiency of transition to OD, and opioid-induced pleasure response. We analyzed potential association betw...

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Bibliographic Details
Main Authors: Feng Zhu, Chun-xia Yan, Yi-chong Wen, Jiayin Wang, Jinbo Bi, Ya-ling Zhao, Lai Wei, Cheng-ge Gao, Wei Jia, Sheng-bin Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3745389?pdf=render