Virulent Type A Francisella tularensis actively suppresses cytokine responses in human monocytes

Virulent Type A Francisella tularensis actively suppresses cytokine responses in human monocytes

Francisella tularensis is a Gram-negative facultative bacterium that can cause the disease tularemia, even upon exposure to low numbers of bacteria. One critical characteristic of Francisella is its ability to dampen or subvert the host immune response. Previous work has shown that monocytes infecte...

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Bibliographic Details
Main Authors: Devyn D Gilette, Heather M Curry, Thomas eCremer, David eRavneberg, Kavin eFatehchad, Prexy eShah, Mark D Wewers, Larry S Schlesinger, Jonathan P Butchar, Susheela eTridandapani, Mikhail A Gavrilin
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Cytokines
Francisella
Monocytes
Signal Transduction
innate immunity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00045/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00045/full

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