In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075

In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075

The bacterial pathogen Acinetobacter baumannii has evolved resistance to many antibiotics, including carbapenems. Here, Wu et al. show that the carbapenemase Oxa-23 interacts with the outer membrane porin CarO in an A. baumanniiisolate, indicative of porin-localised antibiotic inactivation.

Bibliographic Details
Main Authors: Xia Wu, Juan D. Chavez, Devin K. Schweppe, Chunxiang Zheng, Chad R. Weisbrod, Jimmy K. Eng, Ananya Murali, Samuel A. Lee, Elizabeth Ramage, Larry A. Gallagher, Hemantha D. Kulasekara, Mauna E. Edrozo, Cassandra N. Kamischke, Mitchell J. Brittnacher, Samuel I. Miller, Pradeep K. Singh, Colin Manoil, James E. Bruce
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13414

Internet

https://doi.org/10.1038/ncomms13414

Similar Items