Rapamycin Eyedrops Increased CD4<sup>+</sup>Foxp3<sup>+</sup> Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface

Rapamycin Eyedrops Increased CD4<sup>+</sup>Foxp3<sup>+</sup> Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface

Dry eye disease (DED), one of the most prevalent conditions among the elderly, is a chronic inflammatory disorder that disrupts tear film stability and causes ocular surface damage. Aged C57BL/6J mice spontaneously develop DED. Rapamycin is a potent immunosuppressant that prolongs the lifespan of se...

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Bibliographic Details
Main Authors: Claudia M. Trujillo-Vargas, Shallu Kutlehria, Humberto Hernandez, Rodrigo G. de Souza, Andrea Lee, Zhiyuan Yu, Stephen C. Pflugfelder, Mandip Singh, Cintia S. de Paiva
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
aging
ocular surface
lacrimal gland
rapamycin
goblet cell
dry eye
Online Access:https://www.mdpi.com/1422-0067/21/23/8890

Internet

https://www.mdpi.com/1422-0067/21/23/8890

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