PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease

PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease

Worldwide, around 50 million people have dementia. Alzheimer’s disease (AD) is the most common type of dementia and one of the major causes of disability and dependency among the elderly worldwide. Clinically, AD is characterized by impaired memory accompanied by other deficiencies in the cognitive...

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Bibliographic Details
Main Authors: Nabil Itzi Luna-Viramontes, B. Berenice Campa-Córdoba, Miguel Ángel Ontiveros-Torres, Charles R. Harrington, Ignacio Villanueva-Fierro, Parménides Guadarrama-Ortíz, Linda Garcés-Ramírez, Fidel de la Cruz, Mario Hernandes-Alejandro, Sandra Martínez-Robles, Erik González-Ballesteros, Mar Pacheco-Herrero, José Luna-Muñoz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
tau protein
tau pathology
PHF core
truncation
phosphorylation
conformational changes
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00247/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00247/full

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