Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils

Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils

The formation of intracellular aggregates containing α-synuclein (α-Syn) is one of the key steps in the progression of Parkinson's disease and dementia with Lewy bodies. Recently, it was reported that pathological α-Syn fibrils can undergo cell-to-cell transmission and form Lewy body-like aggre...

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Bibliographic Details
Main Authors: Atsushi Tsujimura, Katsutoshi Taguchi, Yoshihisa Watanabe, Harutsugu Tatebe, Takahiko Tokuda, Toshiki Mizuno, Masaki Tanaka
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
Fibril
Aggregate formation
Cathepsin B
Lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003040

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114003040

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