A 2D-QSPR approach to predict blood-brain barrier penetration of drugs acting on the central nervous system

A 2D-QSPR approach to predict blood-brain barrier penetration of drugs acting on the central nervous system

Drugs acting on the central nervous system (CNS) have to cross the blood-brain barrier (BBB) in order to perform their pharmacological actions. Passive BBB diffusion can be partially expressed by the blood/brain partition coefficient (logBB). As the experimental evaluation of logBB is time and cost...

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Bibliographic Details
Main Authors: Matheus Malta de Sá, Kerly Fernanda Mesquita Pasqualoto, Carlota de Oliveira Rangel-Yagui
Format: Article
Language:English
Published: Universidade de São Paulo 2010-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Relações quantitativas bidimensionais entre estrutura química e propriedade (2D-QSPR)
Coeficiente calculado de partição n-octanol/água (ClogP)
Barreira hematoencefálica
Benzodiazepínicos
Two-dimensional quantitative structure-property relationships (2D-QSPR)
Calculated n-octanol/water partition coefficient (ClogP)
Blood-brain barrier
Benzodiazepines
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400016

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400016

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