From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion

From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion

Summary: Glucose-stimulated insulin secretion from islet β cells is mediated by KATP channels. However, the role of non-KATP K+ channels in insulin secretion is largely unknown. Here, we show that a non-KATP K+ channel, KCNH6, plays a key role in insulin secretion and glucose hemostasis in humans an...

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Bibliographic Details
Main Authors: Jin-Kui Yang, Jing Lu, Sha-Sha Yuan, Asan, Xi Cao, Hai-Yan Qiu, Ting-Ting Shi, Fang-Yuan Yang, Qian Li, Cui-Ping Liu, Qian Wu, Yu-Hui Wang, Hai-Xia Huang, Abudurexiti Kayoumu, Jian-Ping Feng, Rong-Rong Xie, Xiao-Rong Zhu, Chang Liu, Guang-Ran Yang, Ming-Rong Zhang, Chun-Lan Xie, Chen Chen, Bo Zhang, George Liu, Xiu-Qing Zhang, Aimin Xu
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718319168

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http://www.sciencedirect.com/science/article/pii/S2211124718319168

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