Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein

Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein

Mutational inactivation of NPC1 largely blocks the movement of LDL-derived cholesterol from the lysosome to the metabolically active, cytosolic pool of sterol that is the substrate for steroid hormone production. Such a block might, in theory, lead to deficiencies in circulating levels of testostero...

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Bibliographic Details
Main Authors: Chonglun Xie, James A. Richardson, Stephen D. Turley, John M. Dietschy
Format: Article
Language:English
Published: Elsevier 2006-05-01
Series:Journal of Lipid Research
Subjects:
adrenal gland
ovary
testis
lipoprotein receptors
corticosterone
testosterone
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520332430

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520332430

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