Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway

Abstract The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in the CSTC pathway is involved in obsessive compulsive disorder (OCD), a neuropsychiatric disorder characterized by the execution of repetitiv...

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Bibliographic Details
Main Authors: Anca Rădulescu, Joanna Herron, Caitlin Kennedy, Annalisa Scimemi
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07527-8