WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.

The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin ta...

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Bibliographic Details
Main Authors: Richard G James, Kathryn C Davidson, Katherine A Bosch, Travis L Biechele, Nicholas C Robin, Russell J Taylor, Michael B Major, Nathan D Camp, Kerry Fowler, Timothy J Martins, Randall T Moon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3515623?pdf=render

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http://europepmc.org/articles/PMC3515623?pdf=render

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