Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability

Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability

Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid. Molecular dynamics studies show that CEP interacts with Voltage-dependent anion channel (VDAC), inducing the voltage-independent channel narrowing. In the new conformation, transport between mitochondria and cytoplasm is altered, which leads t...

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Bibliographic Details
Main Authors: Karolina Cierluk, Wojciech Szlasa, Joanna Rossowska, Mounir Tarek, Anna Szewczyk, Jolanta Saczko, Julita Kulbacka
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Saudi Pharmaceutical Journal
Subjects:
VDAC
Cepharanthine
Neuronal cells
Glioma
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016420302061

Internet

http://www.sciencedirect.com/science/article/pii/S1319016420302061

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